2. Signaling Pathways
  3. Anti-infection
  4. Influenza Virus

Influenza Virus

Influenza Virus

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Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2735
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene
    		Inhibitor
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus.
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene
  • HY-145391
    Triperiden
    		99.88%
    Triperiden is an inhibitor of influenza virus multiplication. Triperiden targets the haemagglutinin of fowl plague virus (FPV) for antiviral activity and acts by inhibiting the conformational change in the haemagglutinin at acid pH. Triperiden is also anticholinergic anti-parkinsonism agent.
    Triperiden
  • HY-138649
    PB2
    		99.88%
    PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs.
    PB2
  • HY-135810A
    Cletoquine oxalate
    		Inhibitor 99.63%
    Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment.
    Cletoquine oxalate
  • HY-125153
    Bursin
    		Inhibitor 99.35%
    Bursin is a peptide that can be isolated from the bursa of Fabricius of chicken. Bursin induces the phenotypic differentiation of mammalian and avian B precursor cells. Bursin also increases cyclic guanosine monophosphate in cells of the human B-cell line Daudi, its derivatives are able to protect against infection by amplifying the immune response induced by H9N2.
    Bursin
  • HY-N11630
    Pinellic acid
    		Inhibitor 99.0%
    Pinellic acid is a natural product that could be isolated from a medicinal plant Pinelliae tuber. Pinellic acid is an effective oral adjuvant for nasal influenza vaccine.
    Pinellic acid
  • HY-13318S1
    Oseltamivir acid-13C,d3
    		Inhibitor
    Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections.
    Oseltamivir acid-<sup>13</sup>C,d<sub>3</sub>
  • HY-121527
    Amylmetacresol
    		Inhibitor 98.89%
    Amylmetacresol is a phenolic compound with topical antibacterial and antiviral activity. Amylmetacresol works by destroying the protein structure of the virus surface or interfering with the function of the virus lipid membrane. Amylmetacresol inhibits the attachment and replication of respiratory viruses such as human Rhinovirus 1a and influenza virus A, without significant effect on viruses such as HRV8. Amylmetacresol is mainly applied topically to the throat to relieve viral sore throats. Amylmetacresol is more active against enveloped viruses than non-enveloped viruses.
    Amylmetacresol
  • HY-Y0017S
    L-Norleucine-d9
    		Inhibitor 99.81%
    L-Norleucine-d9 is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
    L-Norleucine-d<sub>9</sub>
  • HY-N0452R
    Hyperoside (Standard)
    		Inhibitor
    Hyperoside (Standard) is the analytical standard of Hyperoside. This product is intended for research and analytical applications. Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.
    Hyperoside (Standard)
  • HY-128787
    hDHODH-IN-4
    		Inhibitor 99.73%
    hDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC50 of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC50 of 8.8.
    hDHODH-IN-4
  • HY-N0453S
    Hypericin-d10
    		Inhibitor
    Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.
    Hypericin-d<sub>10</sub>
  • HY-Y0017R
    L-Norleucine (Standard)
    		Inhibitor
    L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
    L-Norleucine (Standard)
  • HY-112543
    S119-8
    		Inhibitor 99.73%
    S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV).
    S119-8
  • HY-129150
    Ganoderic acid TR
    		Inhibitor 98.0%
    Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC50 values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses.
    Ganoderic acid TR
  • HY-N0676R
    Dehydroandrographolide (Standard)
    		Inhibitor
    Dehydroandrographolide (Standard) is the analytical standard of Dehydroandrographolide. This product is intended for research and analytical applications. Dehydroandrographolide can be extracted from herbal medicine Andrographis paniculata Nees. Dehydroandrographolide reduces oxidative stress in LPS-induced acute lung injury by inactivating iNOS. Dehydroandrographolide has anti-infective activity.
    Dehydroandrographolide (Standard)
  • HY-P1407
    Z-VRPR-FMK TFA
    		Inhibitor
    Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection.
    Z-VRPR-FMK TFA
  • HY-N8262
    Dehydrocorybulbine chloride
    		Inhibitor
    Dehydrocorybulbine chloride is an isoquinoline alkaloid with neuraminidase (NA) inhibitory activity. Dehydrocorybulbine chloride can be isolated from the 95% ethanol extract of the rhizome of Viola odorata.
    Dehydrocorybulbine chloride
  • HY-N6055
    Nuezhenidic acid
    		99.56%
    Nuezhenidic acid can be isolated from the fruits of Ligustrum lucidum, posseses inhibitory activities against influenza A virus.
    Nuezhenidic acid
  • HY-123304
    MBX2546
    		Inhibitor 99.9%
    MBX2546 is a influenza A virus inhibitor with the Kd values of 5.3μM and ＞ 100 μM for H1 Hemagglutinin and H3 Hemagglutinin, respectively.
    MBX2546
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity